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2002 2
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16 results

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Page 1
Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.
Park IH, Erbay E, Nuzzi P, Chen J. Park IH, et al. Exp Cell Res. 2005 Sep 10;309(1):211-9. doi: 10.1016/j.yexcr.2005.05.017. Exp Cell Res. 2005. PMID: 15963500
An mTOR pathway has also been reported to regulate skeletal muscle hypertrophy, but the regulatory mechanism is not completely understood. Here, we report the investigation of mTOR's function in insulin growth factor I (IGF-I)-induced C2C12 myotube hypertrophy. Adde …
An mTOR pathway has also been reported to regulate skeletal muscle hypertrophy, but the regulatory mechanism is not completely unders …
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.
Shende P, Plaisance I, Morandi C, Pellieux C, Berthonneche C, Zorzato F, Krishnan J, Lerch R, Hall MN, Rüegg MA, Pedrazzini T, Brink M. Shende P, et al. Circulation. 2011 Mar 15;123(10):1073-82. doi: 10.1161/CIRCULATIONAHA.110.977066. Epub 2011 Feb 28. Circulation. 2011. PMID: 21357822
BACKGROUND: Cardiac hypertrophy involves growth responses to a variety of stimuli triggered by increased workload. ...Aortic banding-induced pathological overload resulted in severe dilated cardiomyopathy already at 1 week without a prior phase of adaptive hypertrophy …
BACKGROUND: Cardiac hypertrophy involves growth responses to a variety of stimuli triggered by increased workload. ...Aortic banding- …
The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.
Csibi A, Cornille K, Leibovitch MP, Poupon A, Tintignac LA, Sanchez AM, Leibovitch SA. Csibi A, et al. PLoS One. 2010 Feb 1;5(2):e8994. doi: 10.1371/journal.pone.0008994. PLoS One. 2010. PMID: 20126553 Free PMC article.
The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulat …
The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translationa …
Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy.
Xu J, Chen J, Dong Z, Meyuhas O, Chen JK. Xu J, et al. Kidney Int. 2015 Mar;87(3):543-56. doi: 10.1038/ki.2014.302. Epub 2014 Sep 17. Kidney Int. 2015. PMID: 25229342 Free PMC article.
The molecular mechanism underlying renal hypertrophy and progressive nephron damage remains poorly understood. ...Moreover, the mTORC1 inhibitor rapamycin prevented both rpS6 and 4E-BP1 phosphorylation, significantly blunted uninephrectomy-induced renal hypertrophy …
The molecular mechanism underlying renal hypertrophy and progressive nephron damage remains poorly understood. ...Moreover, the mTORC …
Phosphatidylinositol 3-kinase signaling determines kidney size.
Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC. Chen JK, et al. J Clin Invest. 2015 Jun;125(6):2429-44. doi: 10.1172/JCI78945. Epub 2015 May 18. J Clin Invest. 2015. PMID: 25985273 Free PMC article.
Administration of rapamycin to Pten(ptKO) mice diminished hypertrophy. Proximal tubule-specific deletion of Egfr in Pten(ptKO) mice also attenuated class I PI3K/mTORC2/AKT signaling and reduced the size of enlarged kidneys. In Pten(ptKO) mice, UNX further increased mTORC1 …
Administration of rapamycin to Pten(ptKO) mice diminished hypertrophy. Proximal tubule-specific deletion of Egfr in Pten(ptKO) mice a …
Focused Proteomics Revealed a Novel Rho-kinase Signaling Pathway in the Heart.
Yura Y, Amano M, Takefuji M, Bando T, Suzuki K, Kato K, Hamaguchi T, Hasanuzzaman Shohag M, Takano T, Funahashi Y, Nakamuta S, Kuroda K, Nishioka T, Murohara T, Kaibuchi K. Yura Y, et al. Cell Struct Funct. 2016 Aug 23;41(2):105-20. doi: 10.1247/csf.16011. Epub 2016 Jun 23. Cell Struct Funct. 2016. PMID: 27334702 Free article.
The KISS method showed that ERK and PKA mediated the phosphorylation of known cardiac-substrates of each kinase such as Rps6ka1 and cTnI, respectively. Using this method, we found about 330 proteins as Rho-kinase-mediated substrates, whose substrate in cardiomyocytes is un …
The KISS method showed that ERK and PKA mediated the phosphorylation of known cardiac-substrates of each kinase such as Rps6ka1 and c …
MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.
Pereira AH, Clemente CF, Cardoso AC, Theizen TH, Rocco SA, Judice CC, Guido MC, Pascoal VD, Lopes-Cendes I, Souza JR, Franchini KG. Pereira AH, et al. PLoS One. 2009 Dec 29;4(12):e8472. doi: 10.1371/journal.pone.0008472. PLoS One. 2009. PMID: 20041152 Free PMC article.
BACKGROUND: The activation of the members of the myocyte enhancer factor-2 family (MEF2A, B, C and D) of transcription factors promotes cardiac hypertrophy and failure. However, the role of its individual components in the pathogenesis of cardiac hypertrophy remains …
BACKGROUND: The activation of the members of the myocyte enhancer factor-2 family (MEF2A, B, C and D) of transcription factors promotes card …
Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.
Bostick B, Habibi J, DeMarco VG, Jia G, Domeier TL, Lambert MD, Aroor AR, Nistala R, Bender SB, Garro M, Hayden MR, Ma L, Manrique C, Sowers JR. Bostick B, et al. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1126-35. doi: 10.1152/ajpheart.00898.2014. Epub 2015 Mar 6. Am J Physiol Heart Circ Physiol. 2015. PMID: 25747754 Free PMC article.
Sp administration led to longer sarcomere lengths at each pressure indicative of improved ventricular compliance in WD-fed mice. Sp also prevented left ventricular hypertrophy, interstitial fibrosis, and oxidative stress. Sp prevented the WD-induced increased expression of …
Sp administration led to longer sarcomere lengths at each pressure indicative of improved ventricular compliance in WD-fed mice. Sp also pre …
Chronic high fat feeding attenuates load-induced hypertrophy in mice.
Sitnick M, Bodine SC, Rutledge JC. Sitnick M, et al. J Physiol. 2009 Dec 1;587(Pt 23):5753-65. doi: 10.1113/jphysiol.2009.180174. Epub 2009 Oct 12. J Physiol. 2009. PMID: 19822547 Free PMC article.
In conclusion, chronic high fat feeding impairs the ability of skeletal muscle to hypertrophy in response to increased mechanical load. This failure coincided with a failure to activate key members of the Akt/mTOR signalling pathway and increase protein translation....
In conclusion, chronic high fat feeding impairs the ability of skeletal muscle to hypertrophy in response to increased mechanical loa …
16 results